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Pfizer sues Novo Nordisk, Metsera amid bidding war

Pfizer made good on its threats by filing a lawsuit against Metsera and Novo Nordisk in a mergers and acquisitions bidding war for the obesity-focused biotech.

This follows Novo Nordisk’s last-minute interception of Pfizer’s September 2025 acquisition deal for the New York-based biotech, which could see Pfizer pay up to $7.3 billion for the rights to Metsera.

Through its counteroffer, Novo Nordisk exceeded that value by offering Metsera up to $9 billion, which the biotech deemed a “superior business proposition.”

The lawsuit, filed in Delaware Chancery Court, alleges that Novo Nordisk and Metsera violated the contractual merger agreement, citing “breach of contract, breach of fiduciary duty and tortious interference.”

Pfizer filed additional complaints against Novo Nordisk in its lawsuit announcement, alleging that the Danish pharmaceutical company’s offer to acquire Metsera is an “unlawful attempt by a company with a dominant market position to suppress competition” in the area of ​​obesity, since Novo Nordisk currently holds a dominant market position in that segment.

Pfizer refuted Metsera’s claims that Novo Nordisk’s proposal was superior, noting that it “cannot be characterized as superior” to its deal with Metsera as part of the merger deal. In Pfizer’s view, this is because the Novo Nordisk transaction is unlikely to be completed due to the regulatory risk associated with it.

In a statement released Oct. 31, Metsera said it “disagrees with the allegations contained in Pfizer’s complaint,” adding that the company will respond to them in court.

Despite its sour feelings toward the obesity biotech, Pfizer plans to move forward with the acquisition, which could be ready to close after a Nov. 13 Metsera shareholder meeting.

In an effort to block further debate on this issue, Pfizer also filed a petition in the Court of Chancery seeking a temporary restraining order against Metsera to prevent the biotech from terminating the merger agreement, which Pfizer said would give it “time to be heard on this important issue.”

Despite Novo Nordisk’s attempt to intercept Pfizer’s deal with Metsera, it appears the latter could prevail as the US Federal Trade Commission granted an early end to the waiting period for the New York pharmaceutical company’s pending acquisition.

This back-and-forth comes at a time when Pfizer wants to make a name for itself in the metabolic health sector, which GlobalData estimates will be worth $206.5 billion in 2031, up from $12.3 billion in 2021.

GlobalData is the parent company of Pharmaceutical technology.

Currently, glucagon-like peptide 1 receptor agonists (GLP-1RA) are consistently generating strong business performance, with Eli Lilly’s star assets in type 2 diabetes and obesity, Mounjaro and Zepbound (tirzepatide), bringing in $6.5 billion and $3.6 billion in the third quarter alone, beating analyst expectations and increasing the company’s projected revenue cap for this fiscal year.

Novo Nordisk and Eli Lilly have been the two key players in this segment, fighting for market share with their best-selling injectable GLP-1RAs, Wegovy (semaglutide) and Zepbound.

However, Pfizer has sought to jump on the obesity bandwagon, developing its own assets to compete with therapies marketed by Lilly and Novo Nordisk.

Despite its efforts to develop an oral GLP-1RA, Pfizer had to terminate the development program for its obesity pill, danuglipron, after the drug caused drug-induced liver injury in a phase IIa trial.

If Pfizer’s acquisition of Metsera is completed, the big pharma company will claim Metsera’s portfolio of obesity assets, including monthly GLP-1RA and MET-097i, which recently reported 14.1% weight loss in a Phase IIb trial.

Alongside its portfolio of next-generation injectables, Metsera could offer Pfizer another chance to bring an oral anti-obesity drug to market, as the company’s MET-224o pill is currently in Phase I trials.

“Pfizer Attacks Novo Nordisk and Metsera with Lawsuit Amid Bidding War” was originally created and published by Pharmaceutical Technology, a brand owned by GlobalData.


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